Ophthalmology and Visual Sciences, Department of
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Recent Submissions
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Therapeutic Uses of Scleral Contact Lenses for Ocular Surface Disease: Patient selection and special considerations
(Dove Medical Press, 2018-07-11)Scleral lenses are being prescribed for the management of corneal irregularity, uncomplicated refractive error and ocular surface disease. There are many potential therapeutic uses of scleral lenses in addition to providing ... -
Update on the Ophthalmic Management of Facial Paralysis
(Elsevier, 2019-01)Bell palsy is the most common neurologic condition affecting the cranial nerves. Lagophthalmos, exposure keratopathy, and corneal ulceration are potential complications. In this review, we evaluate various causes of ... -
Evaluation of the underlying causes of papilledema in children
(Elsevier, 2019-04-04)Purpose: The purpose of this retrospective study was to identify the types and relative frequencies of intracranial disorders in pediatric patients who present with papilledema. Methods: This was a retrospective study ... -
Intraocular Light Scatter in Eyes with Boston Type 1 Keratoprosthesis
(Lippincott, Williams & Wilkins, 2018-08)Purpose: Boston Keratoprosthesis (KPro) is the most commonly used artificial cornea. It has been proven to be successful for severe corneal disease not amenable to keratoplasty. We have observed our patients complain of ... -
Pathophysiology and management of glaucoma associated with phakomatoses
(Wiley, 2019-01-01)The phakomatoses, encephalotrigeminal angiomatosis (ETA; Sturge-Weber Syndrome), neurofibromatosis type I (NF1 or von Recklinghausen disease), Von Hippel-Lindau (VHL) disease, tuberous sclerosis (TSC), oculodermal melanocytosis ... -
Update in Current Diagnostics and Therapeutics of Dry Eye Disease
(Elsevier Inc., 2017-11)Dry eye disease (DED) represents a heterogeneous group of conditions with tear film insufficiency and signs and/or symptoms of ocular surface irritation. The clinical manifestations of DED can be highly variable; hence the ... -
Management of Corneal Scarring Secondary to Herpes Zoster Keratitis
(LIPPINCOTT WILLIAMS & WILKINS, 2017-08)Purpose: To review the management of visually significant corneal scarring secondary to herpes zoster keratitis (HZK). Methods: Literature review. Results: Management options for visually significant corneal scarring ... -
Transfer of dynamic motor skills acquired during isometric training to free motion
(American Physiological Society, 2017-03-29)Recent studies have explored the prospects of learning to move without moving, by displaying virtual arm movement related to exerted force. However, it has yet to be tested whether learning the dynamics of moving can ... -
Electroretinography in idiopathic intracranial hypertension: comparison of the pattern ERG and the photopic negative response
(Springer Verlag, 2017-11-14)Purpose To evaluate the relationship between electrophysiological measures of retinal ganglion cell (RGC) function in patients who have idiopathic intracranial hypertension (IIH). Methods The pattern electroretinogram ... -
Late Acute Rejection After Allograft Limbal Stem Cell Transplantation: Evidence for Long-Term Donor Survival.
(Lippincott, Williams & Wilkins, 2017-01-01)Purpose: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. Methods: This was a multicenter, retrospective observational case series. ... -
An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications
(Slack, 2017-02)The vitreoretinal community will remember 2016 as the year that unfavorable anti–platelet-derived growth factor (anti-PDGF) clinical trial results ended the development of Fovista (pegpleranib; Ophthotech, New York, NY) ... -
Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis.
(Springer Verlag, 2016-08-01)PURPOSE: To evaluate rod-isolated, cone-isolated, and combined rod and cone flicker electroretinograms (ERGs) as a possible means to identify electrophysiological abnormalities in carriers of X-linked retinoschisis ... -
Individual differences in scotopic visual acuity and contrast sensitivity: Genetic and non-genetic influences
(Public Library of Science, 2016-02-17)Despite the large amount of variation found in the night (scotopic) vision capabilities of healthy volunteers, little effort has been made to characterize this variation and factors, genetic and non-genetic, that influence ... -
Three-dimensional spectral domain optical coherence tomography and light microscopy of an intravitreal parasite
(Springer Verlag, 2015-12-01)Background: Various imaging modalities play a role in diagnosing parasitic infections of the eye. We describe the spectral domain optical coherence tomography (SD-OCT) findings of an intravitreal parasite with subsequent ... -
Cellular Processing of Myocilin
(Public Library of Science, 2014-04-14)Background: Myocilin (MYOC) is a gene linked directly to juvenile- and adult-onset open angle glaucoma. Mutations including Pro370Leu (P370L) and Gln368stop (Q368X) have been identified in patients. In the present study, ... -
Symptom Burden of Patients with Dry Eye Disease: A Four Domain Analysis
(Public Library of Science, 2013-12-13)Purpose: To determine which sensory (symptom persistence and intensity) and reactive (activity and affective interference) domains of symptom analysis are essential for assessing symptom burden in dry eye disease (DED) ... -
Enface Thickness Mapping and Reflectance Imaging of Retinal Layers in Diabetic Retinopathy
(Public Library of Science, 2015-12-01)Purpose To present a method for image segmentation and generation of enface thickness maps and reflectance images of retinal layers in healthy and diabetic retinopathy (DR) subjects. Methods High density spectral domain ... -
Notch Signaling in Meibomian Gland Epithelial Cell Differentiation.
(Association for Research in Vision and Ophthalmology, 2016-03-01)PURPOSE: Notch1 was previously shown to play a critical role in murine meibomian gland function and maintenance. In this study, we have examined the expression and activation of Notch pathway in human meibomian gland ... -
Bacteria Colonizing the Ocular Surface in Eyes With Boston Type 1 Keratoprosthesis: Analysis of Biofilm-Forming Capability and Vancomycin Tolerance.
(Association for Research in Vision and Ophthalmology, 2015-07)PURPOSE: To analyze the bacterial microbiota colonizing the ocular surface of patients with Boston type 1 keratoprostheses (K-Pros) for antibacterial resistance patterns and capacity to form biofilms. METHODS: Twenty-seven ...