• Development of Co-solvent Freeze-Drying Method for the Encapsulation of Waterinsoluble Thiostrepton in Sterically Stabilized Micelles 

  Esparza, Karina; Onyuksel, Hayat (Elsevier, 2019-02-10)

  The purpose of this work was to develop a practical and scalable method to encapsulate the hydrophobic antibiotic thiostrepton (TST) in sterically stabilized micelles (SSM). Using the conventional method of thin-film ...

• PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα. 

  Hu, X; Huang, F; Szymusiak, M; Tian, X; Liu, Y; Wang, ZJ (Public Library of Science, 2016-01-08)

  Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and ...

• Targeted sterically stabilized phospholipid siRNA nanomedicine for hepatic and renal fibrosis 

  Khaja, F.; Jayawardena, D.; Kuzmis, A.; Önyüksel, H. (MDPI, 2016)

  Since its discovery, small interfering RNA (siRNA) has been considered a potent tool for modulating gene expression. It has the ability to specifically target proteins via selective degradation of messenger RNA (mRNA) not ...

• Regulation and functional significance of CDC42 alternative splicing in ovarian cancer. 

  He, X; Yuan, C; Yang, J (Impact Journals, 2015-10-06)

  Our previous study found that splicing factor polypyrimidine tract-binding protein 1 (PTBP1) had a role in tumorigenesis but the underlying mechanism remained unclear. In this study, we observed that knockdown of PTBP1 ...

• Three-Dimensional Collagen Type I Matrix Up-Regulates Nuclear Isoforms of the Microtubule Associated Protein Tau Implicated in Resistance to Paclitaxel Therapy in Ovarian Carcinoma 

  Gurler, H.; Yu, Y.; Choi, J.; Kajdacsy-Balla, A.A.; Barbolina, M.V. (MDPI, 2015-02-04)

  Epithelial ovarian carcinoma is the deadliest gynecologic malignancy. One reason underlying treatment failure is resistance to paclitaxel. Expression of the microtubule associated protein tau has recently been proposed as ...

• Microfluidic devices to enrich and isolate circulating tumor cells. 

  Myung, JH; Hong, S (Royal Society of Chemistry, 2015-12-21)

  Given the potential clinical impact of circulating tumor cells (CTCs) in blood as a clinical biomarker for the diagnosis and prognosis of various cancers, a myriad of detection methods for CTCs have been recently introduced. ...

• Chemokine Receptors in Epithelial Ovarian Cancer 

  Muralidhar, Goda G; Barbolina, Maria V (MDPI, 2014-01-05)

  Ovarian carcinoma is the deadliest gynecologic malignancy with very poor rate of survival, and it is characterized by the presence of vast incurable peritoneal metastasis. Studies of the role of chemokine receptors, a ...

• Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties. 

  He, X.; Arslan, A.D.; Ho, T-T.; Yuan, C.; Stampfer, M.R.; Beck, W.T. (Nature Publishing Group, 2014-01-13)

  We have investigated some roles of splicing factor polypyrimidine tract-binding protein (PTBP1) in human breast cancer. We found that PTBP1 was upregulated in progressively transformed human mammary epithelial cells (HMECs), ...

• The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer. 

  Muralidhar, GG; Barbolina, MV (MDPI, 2015-07-24)

  The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, ...

• Progress in MicroRNA Delivery 

  Zhang, Yu; Wang, Zaijie; Gemeinhart, Richard A. (Elsevier Inc., 2013-09)

  MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional regulation of gene expression by several mechanisms. Activity is primarily through binding to the 3' untranslated regions (UTRs) of messenger ...

• Curcumin in VIP-Targeted Sterically Stabilized Phospholipid Nanomicelles: A Novel Therapeutic Approach for Breast Cancer and Breast Cancer Stem Cells 

  Gülçür, Ece; Thaqi, Mentor; Khaja, Fatima; Kuzmis, Antonina; Önyüksel, Hayat (Drug Delivery and Translational Research, 2013-12-24)

  Breast cancer is a leading cause of cancer deaths among women in the US, with 40 % chance of relapse after treatment. Recent studies outline the role of cancer stem cells (CSCs) in tumor initiation, propagation, and ...

• Fractalkine receptor is expressed in mature ovarian teratomas and required for epidermal lineage differentiation 

  Rooper, Lisa; Gurler, Hilal; Kajdacsy-Balla, Andre A.; Barbolina, Maria V. (BioMed Central, 2013-08)

  BACKGROUND: The goal of this study was to determine a predominant cell type expressing fractalkine receptor (CX3CR1) in mature ovarian teratomas and to establish functional significance of its expression in cell ...

• Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer 

  White, Bethany Perez; Molloy, Mary Ellen; Zhao, Huiping; Zhang, Yiyun; Tonetti, Debra A. (BioMed Central, 2013-05)

  Background: Prior to the introduction of tamoxifen, high dose estradiol was used to treat breast cancer patients with similar efficacy as tamoxifen, albeit with some undesirable side effects. There is renewed interest to ...

• Understanding nano-bio interactions to improve nanocarriers for drug delivery 

  Pearson, Ryan M.; Hsu, Hao-jui; Bugno, Jason; Hong, Seungpyo (Materials Research Society, 2014-03)

  The ability of cancer-targeted nanoparticles (NPs) to reach their site of action and evoke a desired biological response after intravenous injection is critical to achieve clinically significant in vivo efficacy. Throughout ...

• Dendritic Nanoparticles: The next generation of nanocarriers? 

  Pearson, Ryan M.; Sunoqrot, Suhair; Hsu, Hao-jui; Bae, Jin Woo; Hong, Seungpyo (Future Science Ltd, 2012-08)

  Dendritic polymers have attracted a great deal of scientific interests due to their well-defined unique structure and capability to be multifunctionalized. Here we present a comprehensive overview of various dendrimer-based ...

• Proteolytically activated anti-bacterial hydrogel microspheres 

  Buhrman, Jason S.; Cook, Laura C.; Rayahin, Jamie E.; Federle, Michael J.; Gemeinhart, Richard A. (Elsevier, 2013-11)

  Hydrogels are finding increased clinical utility as advances continue to exploit their favorable material properties. Hydrogels can be adapted for many applications, including surface coatings and drug delivery. Anti-infectious ...

• In-house preparation of hydrogels for batch affinity purification of glutathione S-transferase tagged recombinant proteins 

  Buhrman, Jason S.; Rayahin, Jamie E.; Köllmer, Melanie; Gemeinhart, Richard A. (BioMed Central, 2012-09)

  Background: Many branches of biomedical research find use for pure recombinant proteins for direct application or to study other molecules and pathways. Glutathione affinity purification is commonly used to isolate and ...

• Improvement of drug safety by the use of lipid-based nanocarriers 

  Lim, Sok Bee; Banerjee, Amrita; Önyüksel, Hayat (Elsevier, 2012-10)

  Drug toxicity is an important factor that contributes significantly to adverse drug events in current healthcare practice. Application of lipid-based nanocarriers in drug formulation is one approach to improve drug safety. ...

• VIP-targeted Cytotoxic Nanomedicine for Breast Cancer 

  Dagar, Aparna; Kuzmis, Antonina; Rubinstein, Israel; Sekosan, Marin; Onyuksel, Hayat (Springer Verlag, 2012-12)

  Cancer chemotherapy is hampered by serious toxicity to healthy tissues. Conceivably, encapsulation of cytotoxic drugs in actively-targeted, biocompatible nanocarriers could overcome this problem. Accordingly, we used ...

• Let-7 micro RNAs and opioid tolerance 

  He, Ying; Wang, Zaijie Jim (Frontiers Research Foundation, 2012-06-21)

  This chapter will focus on the role of microRNAs (miRs) in regulating the actions of opioid drugs through the opioid receptors. Opioids, such as morphine, are analgesics that are used for treating many forms of acute and ...

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