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Overactivation of intestinal SREBP2 in mice increases serum cholesterol
(Public Library of Science, 2014-01-20)
Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis. Treatment with statins, inhibitors of cholesterol synthesis, activates intestinal SREBP2, which may ...
Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models
The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, ...