Now showing items 1-10 of 19
Cognitive Informatics in Biomedicine and Healthcare
(Elsevier Inc., 2015)
A Vps21 endocytic module regulates autophagy.
(American Society for Cell Biology, 2014-10-15)
In autophagy, the double-membrane autophagosome delivers cellular components for their degradation in the lysosome. The conserved Ypt/Rab GTPases regulate all cellular trafficking pathways, including autophagy. These GTPases ...
Obestatin Plays an Opposite Role in the Regulation of Pituitary Somatotrope and Corticotrope Function in Female Primates and Male/Female Mice
(Endocrine Society, 2014-04)
Obestatin is a 23-amino-acid amidated peptide that is encoded by the ghrelin gene. Previous studies have shown obestatin can modulate the hypothalamic neuronal circuitry that regulates pituitary function, perhaps by ...
Comprehensive Analysis of Herpes Simplex Virus 1 (HSV-1) Entry Mediated by Zebrafish 3-O-Sulfotransferase Isoforms: Implications for the Development of a Zebrafish Model of HSV-1 Infection
(American Society for Microbiology, 2014-11)
Binding of herpes simplex virus 1 (HSV-1) envelope glycoprotein D (gD) to the receptor 3-O-sulfated heparan sulfate (3-OS HS) mediates viral entry. 3-O-Sulfation of HS is catalyzed by the 3-O-sulfotransferase (3-OST) enzyme. ...
Characterizing Spatial Patterns of Airborne Coarse Particulate (PM10–2.5) Mass and Chemical Components in Three Cities: The Multi-Ethnic Study of Atherosclerosis
(National Institute of Environmental Health Sciences, 2014-08)
Background: The long-term health effects of coarse particular matter (PM10–2.5) are challenging to assess because of a limited understanding of the spatial variation in PM10–2.5 mass and its chemical components. Objectives: ...
Evidence for Fibroblast Growth Factor-2 as a Mediator of Amphetamine-Enhanced Motor Improvement following Stroke
(Public Library of Science, 2014-09-17)
Previously we have shown that addition of amphetamine to physical therapy results in enhanced motor improvement following stroke in rats, which was associated with the formation of new motor pathways from cortical projection ...
A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets
(Nature Publishing Group, 2014-12-05)
Stable and efficient knockdown of multiple gene targets is highly desirable for dissection of molecular pathways. Because it allows sequence-specific DNA binding, transcription activator-like effector (TALE) offers a new ...
CD45 ligation expands Tregs by promoting interactions with DCs
(American Society for Clinical Investigation, 2014-10)
Tpz1-Ccq1 and Tpz1-Poz1 Interactions within Fission Yeast Shelterin Modulate Ccq1 Thr93 Phosphorylation and Telomerase Recruitment
(Public Library of Science, 2014-10-16)
In both fission yeast and humans, the shelterin complex plays central roles in regulation of telomerase recruitment, protection of telomeres against DNA damage response factors, and formation of heterochromatin at telomeres. ...
Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells
Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for the production of transfusable platelets. Here, we describe a method to generate megakaryocytes (MKs) and functional platelets ...