Now showing items 1-10 of 32
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
(Elsevier (Cell Press), 2016-07-12)
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to ...
Bioenergetic shifts during transitions between stem cell states
(Pulmonary Circulation, 2014-09-01)
Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell ...
SLIT3–ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo
(Journal of Molecular and Cellular Cardiology, 2013-11-01)
Successful implantation and long-term survival of engineered tissue grafts hinges on adequate vascularization of the implant. Endothelial cells are essential for patterning vascular structures, but they require supportive ...
There Was No Couch: On Mental Illness and Creativity
Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells
(Public Library of Science, 2013)
Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated from bone marrow, adipose tissue as well as other tissues and have the capacity to differentiate into a variety of mesenchymal cell ...
Moral Time: Does Our Internal Clock Influence Moral Judgments?
(www.3Quarksdaily.com. http://www.3quarksdaily.com/3quarksdaily/2014/10/moral-time-does-our-internal-clock-influence-moral-judgments.html, 2014-10-13)
Does morality depend on the time of the day? The study The Morning Morality Effect: The Influence of Time of Day on Unethical Behavior (1) published in October of 2013 by Maryam Kouchaki and Isaac Smith suggested that ...
Haikus and Landays in Science
Heat not Wet: Climate Change Effects on Human Migration in Rural Pakistan
The 2010 floods were among the worst that Pakistan has experienced in recent decades. Sadly, the country is prone to recurrent flooding, which means that in any given year, Pakistani farmers hope and pray that the floods ...
The “Invisible Web” Undermines Health Information Privacy
The study Privacy Implications of Health Information Seeking on the Web, conducted by Tim Libert at the Annenberg School for Communication (University of Pennsylvania), shows that we have a for more nonchalant attitude ...
Flk1+ and VE-Cadherin+ Endothelial Cells Derived from iPSCs Recapitulates Vascular Development during Differentiation and Display Similar Angiogenic Potential as ESC-Derived Cells
(PLoS One, 2014-01-05)
This work was supported by grants from the National Institutes of Health to KKW (HL079356), MUF (HL112293), JR (GM094220), and ABM (HL090152), and awards from the American Heart Association to EEK (12PRE1208000) and KKW ...