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    • EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease 

      Tai, LM; Balu, D; Avila-Munoz, E; Abdullah, L; Thomas, R; Collins, N; Valencia-Olvera, AC; LaDu, MJ (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-09)
      Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 ...