Endocrinology, Diabetes and Metabolism, Section of
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The Association between Daytime Napping Characteristics and Bone Mineral Density in Elderly Thai Women without Osteoporosis
(Nature Research, 2018-07-03)Low bone mass is more prevalent with increasing age. Studies have found associations between sleep duration, sleep quality and obstructive sleep apnea and bone mineral density (BMD). However, less is known about the ... -
Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease
(Wiley, 2017-08)ObjectivesH(2)O(2) contributes to FID of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase ... -
Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children
(BioScientifica, 2018-02-16)With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine ... -
Effects of Bedroom Environmental Conditions on the Severity of Obstructive Sleep Apnea
(American Academy of Sleep Medicine, 2018-04)STUDY OBJECTIVES: Epidemiological associations have demonstrated the effects of long-term air pollution to obstructive sleep apnea (OSA) through a physiological mechanism linking particulate matter exposure to OSA. This ... -
Microvascular vasodilator plasticity following acute exercise
(American College of Sports Medicine, 2018-01-01)Endothelium-dependent vasodilation is reduced following acute exercise, or following high intraluminal pressure in isolated arterioles from sedentary adults, but not in arterioles from regular exercisers. The preserved ... -
Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion
(Lippincott, Williams & Wilkins, 2017-12-01)Critical aspects of maintaining glucose homeostasis in the face of chronic insulin resistance and type 2 diabetes (T2D) are increased insulin secretion and adaptive expansion of beta cell mass. Nutrient and hormone sensing ... -
Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins.
(Elsevier Inc., 2016-04-12)Metabolism is a highly integrated process that is coordinately regulated between tissues and within individual cells. FoxO proteins are major targets of insulin action and contribute to the regulation of gluconeogenesis, ... -
Efficacy and Safety of an Octreotide Implant in the Treatment of Patients With Acromegaly
(Endocrine Society, 2013-10)Context: Acromegaly is caused by excessive GH secretion and IGF-I overproduction. The goals of treatment are to reduce GH and IGF-I values to normal and relieve the associated symptoms. Objective: The purpose of this ... -
Obestatin Plays an Opposite Role in the Regulation of Pituitary Somatotrope and Corticotrope Function in Female Primates and Male/Female Mice
(Endocrine Society, 2014-04)Obestatin is a 23-amino-acid amidated peptide that is encoded by the ghrelin gene. Previous studies have shown obestatin can modulate the hypothalamic neuronal circuitry that regulates pituitary function, perhaps by ... -
Similarities and differences between patients included and excluded from a randomized clinical trial of vitamin d supplementation for improving glucose tolerance in prediabetes: interpreting broader applicability.
(BioMed Central, 2015-07-15)Background: Randomized Clinical Trial (RCT) designs range from highly selective resulting in lack of external validity to more inclusive, requiring large sample sizes to observe significant results. Few publications, ... -
Skeletal Muscle Vascular Function: A Counterbalance of Insulin Action.
(Wiley Online Library, 2015-07)Insulin is a vasoactive hormone that regulates vascular homeostasis by maintaining balance of endothelial derived nitric oxide (NO) and the potent vasoconstrictor, endothein-1 (ET-1). Although there is general agreement ... -
Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.
(American Diabetes Association, 2015-09)Patients with nonalcoholic fatty liver disease (NAFLD) are reported to have low growth hormone (GH) production and/or hepatic GH resistance. GH replacement can resolve the fatty liver condition in diet-induced obese rodents ... -
Metabolic dysfunction in obese Hispanic women with PCOS
(Oxford University Press, 2015-06)Study question: Are certain ethnic groups with PCOS at increased risk of metabolic disorders? Summary answer: Obese Hispanic women with PCOS are at increased risk of metabolic disorders compared to age- and BMI-matched ... -
Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial
(BioMed Central, 2013-07)Background: The prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for the development of innovative therapeutic approaches to overcome ... -
PCOS Is Associated with Increased CD11c Expression and Crown-Like Structures in Adipose Tissue and Increased Central Abdominal Fat Depots Independent of Obesity
(Endocrine Society, 2013-01)CONTEXT: Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS. OBJECTIVE: We tested whether ... -
The Rise in Growth Hormone during Starvation Does Not Serve to Maintain Glucose Levels or Lean Mass but Is Required for Appropriate Adipose Tissue Response in Female Mice
(Endocrine Society, 2013-01)In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using ... -
Endogenous Somatostatin Is Critical in Regulating the Acute Effects of L-Arginine on Growth Hormone and Insulin Release in Mice
(Endocrine Society, 2013-07)L-arginine (L-Arg) rapidly stimulates GH and insulin release in vivo. It has been hypothesized that L-Arg stimulates GH release by lowering hypothalamic somatostatin (SST) tone. L-Arg may also act directly at the pituitary ... -
Synovial sarcoma of the lung in a patient who received radioactive iodine therapy for thyroid cancer
(Mary Ann Liebert, 2012-12)Background: Synovial sarcomas are uncommon malignancies that mainly affect adolescents and young adults. Most arise from the deep soft tissues of the extremities, but they can occur in other parts of the body such as the ... -
Cortistatin Is Not a Somatostatin Analogue but Stimulates Prolactin Release and Inhibits GH and ACTH in a Gender-Dependent Fashion: Potential Role of Ghrelin
(Endocrine Society, 2011-12)Cortistatin (CST) and somatostatin (SST) evolve from a common ancestral gene and share remarkable structural, pharmacological, and functional homologies. Although CST has been considered as a natural SST-analogue acting ... -
A Piece of the Puzzle: What Does BRAF Status Mean in the Management of Patients with Papillary Thyroid Carcinoma?
(Endocrine Society, 2012-09)
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