Publications - Cancer Biology and Pharmacology
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Allergies, antibiotics use, and multiple sclerosis
(TAYLOR & FRANCIS LTD, 2017)Background: The associations between allergies, antibiotics use, and multiple sclerosis (MS) remain controversial and their mediating or moderating effects have not yet been examined. We aimed to assess the direct and ... -
Long-term risk of colorectal cancer by gender after positive colonoscopy: population-based cohort study.
(Taylor & Francis, 2016-04)Background: Evidence for surveillance intervals of colonoscopy are primarily based on adenoma recur-rence rate rather than on colorectal cancer (C.R.C.) incidence. Little is known about long-term risk of C.R.C. after ... -
Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis
(Nature Publishing Group, 2013-06)The expression of urokinase-type plasminogen activator (uPA) receptor (uPAR) correlates with the malignant phenotype of various cancers. The soluble form of uPAR (s-uPAR) is present in the circulation of cancer patients, ... -
Regulation of Proteases after Spinal Cord Injury
(Mary Ann Liebert, 2012-09)Spinal cord injury is a major medical problem worldwide. Unfortunately, we still do not have suitable therapeutic agents for the treatment of spinal cord injury and prevention of its devastating consequences. Scientists and ... -
Suppression of Tumor Cell Invasiveness and In Vivo Tumor Growth by MicroRNA-874 in Non-Small Cell Lung Cancer
(Elsevier Inc., 2013-05)MicroRNAs are a novel family of small non-coding RNAs that regulate the expression of several genes involved in normal development as well as human disorders including cancer. Here we show that miR-874 plays a tumor ... -
MMP-9 and uPAR regulated glioma cell migration
(Landes Bioscience, 2012-11)Integrin dependent and independent MMP-9 and uPAR signaling plays a key role in glioma cell migration and invasion. In this article, we comment on all the possible pathways and molecules associated with MMP-9- and uPAR- ... -
Transcriptional Repression of Mad-Max Complex by Human Umbilical Cord Blood Stem Cells Downregulates Extracellular Signal-Regulated Kinase in Glioblastoma
(Mary Ann Liebert, 2012-07)Previously, we have shown that human umbilical cord blood stem cell (hUCBSC) treatment downregulate cyclin D1 in glioma cells. To study the cell cycle progression and investigate the upstream molecules regulating cyclin ... -
Transcriptional Repression of Mad-Max Complex by Human Umbilical Cord Blood Stem Cells Downregulates Extracellular Signal-Regulated Kinase in Glioblastoma
(Mary Ann Liebert, 2012-07)Previously, we have shown that human umbilical cord blood stem cell (hUCBSC) treatment downregulate cyclin D1 in glioma cells. To study the cell cycle progression and investigate the upstream molecules regulating cyclin D1 ... -
Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
(Public Library of Science, 2012-09)Background: Medulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in ... -
Drugs in preclinical and early stage clinical development for pancreatic cancer
(Informa Healthcare, 2012-02)Introduction: Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in the U.S. and Europe and the lethality of this cancer is demonstrated by the fact that the annual incidences are approximately ... -
Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer
(American Society for Cell Biology, 2013-09)Pancreatic ductal adenocarcinoma (PDAC) is almost always lethal. One of the underlying reasons for this lethality is believed to be the presence of cancer stem cells (CSC), which impart chemoresistance and promote recurrence, ... -
SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
(Public Library of Science, 2012)Secreted protein acidic and rich in cysteine (SPARC) is also known as BM-40 or Osteonectin, a multi-functional protein modulating cell–cell and cell–matrix interactions. In cancer, SPARC is not only linked with a highly ... -
Cord Blood Stem Cells Inhibit Epidermal Growth Factor Receptor Translocation to Mitochondria in Glioblastoma
(Public Library of Science, 2012-02)Background: Overexpression of EGFR is one of the most frequently diagnosed genetic aberrations of glioblastoma multiforme (GBM). EGFR signaling is involved in diverse cellular functions and is dependent on the type of ... -
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease
(BioMed Central, 2011-08)Background: Amyloid plaques, a pathological hallmark of Alzheimer’s disease (AD), are accompanied by activated microglia. The role of activated microglia in the pathogenesis of AD remains controversial: either clearing ... -
Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease
(Elsevier, 2012-03)We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22 months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and ... -
Intermittent Hypoxia Regulates Stem-like Characteristics and Differentiation of Neuroblastoma Cells
(Public Library of Science, 2012-02)Background: Neuroblastomas are the most common extracranial solid tumors in children. Neuroblastomas are derived from immature cells of the sympathetic nervous system and are characterized by clinical and biological ... -
Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice
(Public Library of Science, 2011-10-14)Background: Glioblastoma Multiforme (GBM) is the most lethal form of brain tumor. Efficient DNA repair and anti-apoptotic mechanisms are making glioma treatment difficult. Proteases such as MMP9, cathepsin B and urokinase ... -
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
(BioMed Central, 2011-10)Background: uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion. Previous studies from our lab have also shown that uPA/uPAR down ... -
Role of MDR1 C3435T and GABRG2 C588T Gene Polymorphisms in Seizure Occurrence and MDR1 Effect on Anti-Epileptic Drug (Phenytoin) Absorption
(Mary Ann Liebert, 2012)Aims: To assess the role of MDR1 and gamma-aminobutyric acid receptor–gamma 2 sub unit (GABRG2) gene polymorphism in seizure susceptibility in generalized seizure (GS) and febrile seizure (FS) patients and to evaluate ... -
Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
(Public Library of Science, 2010-04-26)Background: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor gene implicated in a wide variety of human cancers, including glioblastoma. PTEN is a major negative regulator of the ...
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