• Single Stream Inertial Focusing in Low Aspect-Ratio Triangular Microchannels 

  Mukherjee, Prithviraj; Wang, Xiao; Zhou, Jian; Papautsky, Ian (Royal Society of Chemistry, 2018-11-29)

  A wide range of microfluidic devices for single stream focusing of cells and particles has emerged in recent years, based on both passive and active methods. Inertial microfluidics offers an attractive alternative to these ...

• Cellular Obstruction Clearance in Proximal Ventricular Catheters Using Low-voltage Joule Heating 

  Sane, Abhay; Tangen, Kevin; Frim, David; Singh, Meenesh R.; Linninger, Andreas (Institute of Electrical and Electronics Engineers (IEEE), 2018-02)

  Objective: Proximal obstruction due to cellular material is a major cause of shunt failure in hydrocephalus management. The standard approach to treat such cases involves surgical intervention which unfortunately is ...

• CASTp 3.0: Computed Atlas of Surface Topography of proteins 

  Tian, Wei; Chang, Chen; Lei, Xue; Zhao, Jieling; Zhao, Jieling (Oxford University Press, 2018-06-02)

  Geometric and topological properties of protein structures, including surface pockets, interior cavities and cross channels, are of fundamental importance for proteins to carry out their functions. Computed Atlas of Surface ...

• In vivo Diffusion MRI Detects Early Changes in Spinal Cord Axonal Pathology in a Mouse Model of Amyotrophic Lateral Sclerosis 

  Gatto, Rodolfo, G.; Li, Weiguo; Gao, Jin; Magin, Richard, L. (Wiley, 2018-08-31)

  Diffusion magnetic resonance imaging (MRI) exhibits contrast that identifies macro- and microstructural changes in neurodegenerative diseases. Previous studies have shown that MR diffusion tensor imaging (DTI) can observe ...

• Simultaneous Magnetic Resonance and Optical Elastography Acquisitions: Comparison of Displacement Images and Shear Modulus Estimations using a Single Vibration Source 

  Brinker, Spencer; Kearney, Steven P.; Royston, Thomas J.; Klatt, Dieter (Elsevier, 2018-08-01)

  The mechanical properties of tissue are sensitive to pathological changes, which is the basis for using dynamic elastography as a diagnostic tool. The purpose of this study is a concurrent cross-modality comparison of two ...

• MoonProt 2.0: An expansion and update of the moonlighting proteins database 

  Chen, Chang; Zabad, Shadi; Liu, Haipeng; Wang, Wangfei; Jeffery, Constance (Oxford University Press, 2018-01-04)

  MoonProt 2.0 (http://moonlightingproteins.org) is an updated, comprehensive and open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins contain two or more physiologically ...

• Determination of Manganese in Whole Blood by Cathodic Stripping Voltammetry with Indium Tin Oxide 

  Rusinek, CA; Kang, WJ; Nahan, K; Hawkins, M; Quartermaine, C; Stastny, A; Bange, A; Papautsky, I; Heineman, WR (WILEY-V C H VERLAG GMBH, 2017-08)

  Manganese (Mn) is a required trace metal in the body. In recent years however, it has garnered significant attention as a developmental neurotoxin in children with chronic exposure. It has been linked to complications such ...

• Efficient computation of transfer free energies of amino acids in beta-barrel membrane proteins 

  Tian, W; Lin, M; Naveed, H; Liang, J (Oxford University Press, 2017-06)

  Motivation: Transmembrane beta-barrel proteins (TMBs) serve a multitude of essential cellular functions in Gram-negative bacteria, mitochondria and chloroplasts. Transfer free energies (TFEs) of residues in the transmembrane ...

• A high throughput microfluidic platform for size-selective enrichment of cell populations in tissue and blood samples 

  Nivedita, N; Garg, N; Lee, AP; Papautsky, I (Royal Society of Chemistry, 2017-07-21)

  Numerous applications in biology and medicine require the efficient and reliable separation of cells for disease diagnosis, genetic analysis, drug screening, and therapeutics. In this work, we demonstrate a novel technology ...

• Multi-omics facilitated variable selection in Cox-regression model for cancer prognosis prediction 

  Liu, C; Wang, X; Genchev, GZ; Lu, H (Academic Press Inc., 2017-07)

  Motivation New developments in high-throughput genomic technologies have enabled the measurement of diverse types of omics biomarkers in a cost-efficient and clinically-feasible manner. Developing computational methods and ...

• Magnetic Resonance in the Assessment of Tissue Engineered Cartilage 

  Kotecha, Mrignayani; Yin, Ziying; Magin, Richard L. (Royal Society of Chemistry, 2016-11-16)

  Magnetic resonance spectroscopy (MRS) and imaging (MRI) are routinely used for non-invasive monitoring and assessment of cartilage regeneration in vitro and in vivo. Cartilage tissue engineering utilizes a combination of ...

• A polyelectrolyte multilayer platform for investigating growth factor delivery modes in human liver cultures 

  Lin, Christine; Romero, Raimundo; Sorokina, Lioudmila, V.; Ballinger, Kimberly, R.; Place, Laura, W.; Kipper, Matt, J.; Khetani, Salman, R. (Wiley, 2017-11-15)

  Polyelectrolyte multilayers (PEMs) of chitosan and heparin are useful for mimicking growth factor (GF) binding to extracellular matrix (ECM) as in vivo. Here, we developed a PEM platform for delivering bound/adsorbed GFs ...

• Smartphone-based imaging of the corneal endothelium at sub-cellular resolution 

  Toslak, Devrim; Thapa, Damber; Erol, Muhammet, K.; Chen, Yanjun; Yao, Xincheng (Taylor & Francis, 2016-12-25)

  This aim of this study was to test the feasibility of smartphone-based specular microscopy of the corneal endothelium at a sub-cellular resolution. Quantitative examination of endothelial cells is essential for evaluating ...

• Mechanism of OmpG pH-Dependent Gating from Loop Ensemble and Single Channel Studies 

  Perez-Rathke, Alan; Fahie, Monifa, A.; Chisholm, Christina; Liang, Jie; Chen, Min (American Chemical Society, 2017-12-20)

  Outer membrane protein G (OmpG) from Escherichia coli has exhibited pH-dependent gating that can be employed by bacteria to alter the permeability of their outer membranes in response to environmental changes. We developed ...

• High-resolution structure prediction of β-barrel membrane proteins 

  Tian, Wei; Lin, Meishan; Tang, Ke; Liang, Jie; Naveed, Hammad (National Academy of Sciences, 2018-01-29)

  β-Barrel membrane proteins (βMPs) play important roles, but knowledge of their structures is limited. We have developed a method to predict their 3D structures. We predict strand registers and construct transmembrane (TM) ...

• Development of a point-of-care diagnostic for influenza detection with antiviral treatment effectiveness indication. 

  Murdock, R.C.; Gallegos, K.M.; Hagen, J.A.; Kelley-Loughnane, N.; Weiss, A.A.; Papautsky, I (Royal Society of Chemistry, 2017-02)

  Currently, diagnosis of influenza is performed either through tedious polymerase chain reaction (PCR) or through rapid antigen detection assays. The rapid antigen detection assays available today are highly specific but ...

• Distance-Guided Forward and Backward Chain-Growth Monte Carlo Method for Conformational Sampling and Structural Prediction of Antibody CDR-H3 Loops 

  Tang, K.; Zhang, J.F.; Liang, J. (American Chemical Society, 2016-11-30)

  Antibodies recognize antigens through the complementary determining regions (CDR) formed by six-loop hypervariable regions crucial for the diversity of antigen specificities. Among the six CDR loops, the H3 loop is the ...

• The capillary bed offers the largest hemodynamic resistance to the cortical blood supply 

  Linninger, Andreas; Kleinfeld, David; Tsai, Philbert; Gould, Ian Gopal (Nature Publishing Group, 2017-01)

  The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen metabolism. Difficulties in imaging the microanatomy of the cortex have restricted insight about microcirculatory blood flow ...

• Magnetic field-enhanced cellular uptake of doxorubicin-loaded magnetic nanoparticles for tumor treatment 

  Venugopal, Indu; Pernal, Sebastian; Duproz, Alexandra; Bentley, Jeromy; Engelhard, Herbert; Linninger, Andreas (Institute of Physics, 2016-09-02)

  Cancer remains the second most common cause of death in the US, accounting for nearly 1 out of every 4 deaths. In recent years, several varieties of nanoparticles (NPs) have been synthesized with the intent of being ...

• Vacuum pressure generation via microfabricated converging-diverging nozzles for operation of automated pneumatic logic 

  Christoforidis T; Werner EM; Hui EE; Eddington DT (Springer Verlag, 2016-08)

  Microfluidic devices with integrated pneumatic logic enable automated fluid handling without requiring external control instruments. These chips offer the additional advantage that they may be powered by vacuum and do ...

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