Publications - Dermatology
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IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes
(Wiley, 2018-11)IL-4 plays an important role in atopic dermatitis (AD) pathogenesis by dysregulating many key factors at the transcriptional level. In this study, using microRNA array technique and IL-4 transgenic mice, we demonstrated ... -
Disseminated Herpes Simplex Virus presenting as crusted papules on the palms and soles of an immunosuppressed patient.
(University of California, Davis, 2014-09)Disseminated Herpes Simplex Virus (HSV) may occur in immunosuppressed patients, most commonly causing visceral organ involvement and rarely presenting solely with cutaneous lesions. We report an interesting case of ... -
Hair-thread tourniquet syndrome: a case report and review of treatment.
(Dermatology Online Journal, 2014-10-15)Hair-thread tourniquet syndrome (HTTS) is caused by circumferential constriction of an appendage, usually by hair or thread, leading to obstruction of circulation and ischemia. Although not rare, this entity is not ... -
Successful long-term thalidomide therapy for discoid lupus erythematosus-lichen planus overlap syndrome
(University of California, Davis, 2014-10)Although thalidomide is a U.S. Food and Drug Admistration (FDA) approved medication for erythema nodosum leprosum and multiple myeloma, it has many off-label uses, including for discoid lupus erythematosus (DLE), Behçet’s ... -
Apocrine Hidrocystoma of the Urethral Meatus: A Case Report
(Society for Publication of Acta Dermato-Venereologica, 2015-03-01)Apocrine hidrocystomas (cystadenomas) are cystic cu - taneous neoplasms derived from apocrine sweat glands (1, 2), and they most often present in adults as solitary (rarely multiple) lesions involving the head, ... -
Structure–Function Analysis of the NonMuscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants
(Public Library of Science, 2015-06-25)The MYLK gene encodes the multifunctional enzyme, myosin light chain kinase (MLCK), involved in isoform-specific non-muscle and smooth muscle contraction and regulation of vascular permeability during inflammation. Three ... -
Prospective Study of Wound Infections in Mohs Micrographic Surgery Using a Single Set of Instruments.
(Lippincott, Williams & Wilkins, 2015-09)BACKGROUND: Mohs micrographic surgery (MMS) has a low rate of surgical site infections (SSI). To date, there are variations in the measures surgeons take to prevent SSI, although these may be costly without benefit to ... -
Disseminated Herpes Simplex Virus presenting as crusted papules on the palms and soles of an immunosuppressed patient
(Dermatology Online Journal, 2014-09)Disseminated Herpes Simplex Virus (HSV) may occur in immunosuppressed patients, most commonly causing visceral organ involvement and rarely presenting solely with cutaneous lesions. We report an interesting case of ... -
IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis
(Elsevier, 2013-02)Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify ... -
Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms
(National Academy of Sciences, 2012-07-31)Many types of embryos’ bodyplans exhibit consistently-oriented laterality of the heart, viscera, and brain. Errors of left-right patterning present an important class of human birth defects, and considerable controversy ... -
Assessing students' ability to detect melanomas using standardized patients and moulage
(Elsevier, 2011-12)Detection of melanoma by physicians via opportunistic surveillance during focused physical examinations may reduce mortality. Medical students may not encounter a clinical case of melanoma during a dermatology clerkship. -
IL-4 Regulates Chemokine CCL26 in Keratinocytes through the Jak1, 2/Stat6 Signal Transduction Pathway: Implication for Atopic Dermatitis
(Elsevier, 2012-02)Atopic dermatitis (AD), a chronic, pruritic, inflammatory skin disease, is histopathologically characterized by epidermal hyperplasia and infiltration of T cells, mast cells, and eosinophils. Clinical study and basic ... -
Ocular and Oral Mucous Membrane Pemphigoid (Cicatricial Pemphigoid)
(Elsevier, 2012)Mucous membrane pemphigoid, a heterogeneous group of autoimmune blistering diseases, affect primarily the mucous membranes. While both oral and ocular mucosae can be affected in a given patient, patients have involvement ... -
VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model
(Nature Publishing Group, 2010-01-12)We investigated the roles of critical adhesion molecules ICAM-1 and VCAM-1 in a keratin-14 IL-4 transgenic (Tg) mouse model of atopic dermatitis, the skin lesions of which are characterized by prominent inflammatory cell ...
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