Now showing items 1-8 of 8
MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation
Background: Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic ...
MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness
(Cambridge University Press, 2011-11)
MicroRNA (miRNA) expression was measured within frontal cortex of male Holtzman rats subjected to repeated inescapable shocks at days 1 and 7, tested for learned helplessness (LH) at days 2 and 8, and sacrificed at day ...
Is Timing Everything? New Insights into Why the Effect of Estrogen Therapy on Memory Might be Age Dependent
(Endocrine Society, 2013-08)
Endogenous Somatostatin Is Critical in Regulating the Acute Effects of L-Arginine on Growth Hormone and Insulin Release in Mice
(Endocrine Society, 2013-07)
L-arginine (L-Arg) rapidly stimulates GH and insulin release in vivo. It has been hypothesized that L-Arg stimulates GH release by lowering hypothalamic somatostatin (SST) tone. L-Arg may also act directly at the pituitary ...
Abnormal gene expression of proinflammatory cytokines and their receptors in the lymphocytes of patients with bipolar disorder.
Objectives: Abnormalities of protein levels of proinflammatory cytokines and their soluble receptors have been reported in plasma of bipolar (BP) patients. In this study we tested the hypothesis that the mRNA expression ...
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
(Cold Spring Harbor Laboratory Press, 2013-11)
V(D)J joining is mediated by RAG recombinase during early B-lymphocyte development in the bone marrow (BM). Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoid structures. ...
Pharmacogenomic Discovery Delineating the Genetic Basis of Drug Response
(Springer Verlag, 2013-09)
Personalized medicine has the promise to tailor medical care based on the patient’s genetic make-up and clinical variables such as gender, race and exposure to environmental stimuli. Recent progress in pharmacogenetic and ...
Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease
(American Heart Association, 2014-04-22)
Background. We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. Methods and Results. To ...