Publications - Pathology
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Dimensions of hepatocellular carcinoma phenotypic diversity
(Baishideng Publishing Group, 2018-10)Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and ... -
Primary liver diffuse large B-cell lymphoma following complete response for hepatitis C infection after direct antiviral therapy.
(Karger Publishers, 2018-01-26)INTRODUCTION: Hepatitis C infection is highly prevalent worldwide and has a well-known association with B-cell lymphoid malignancies. Antiviral therapy has successfully decreased the rate of liver cirrhosis and improved ... -
Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer.
(BioMed Central, 2016-02-29)BACKGROUND: Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increased ... -
In Vitro Activity of Retapamulin and Antimicrobial Susceptibility Patterns in a Longitudinal Collection of Methicillin-Resistant Staphylococcus aureus Isolates from a Veterans Affairs Medical Center.
(American Society for Microbiology, 2016-03-01)Mupirocin is a topical antimicrobial used to decolonize patients who carry methicillin-resistant Staphylococcus aureus (MRSA), and the topical agent retapamulin may be a potential alternative therapy. The goal of this study ... -
Breast cancer diagnosis using spatial light interference microscopy.
(Society of Photo-optical Instrumentation Engineers, 2015-11-01)The standard practice in histopathology of breast cancers is to examine a hematoxylin and eosin (H&E) stained tissue biopsy under a microscope to diagnose whether a lesion is benign or malignant. This determination is made ... -
Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans.
(Frontiers Media, 2016-02-22)Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still ... -
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.
(Elsevier (Cell Press), 2015-11-24)TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2 deletion in mice causes myeloid ... -
Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy.
(American Society of Clinical Oncology, 2016-04-30)Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate-risk disease, vitamin D may ... -
The role of adherens junctions in the developing neocortex
(Taylor & Francis, 2015-06)The disproportional enlargement of the neocortex through evolution has been instrumental in the success of vertebrates,in particular mammals. The neocortex is a multilayered sheet of neurons generated from a simple ... -
Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27
(Spandidos Publications, 2014-07)Selenium is an essential trace element and has shown chemopreventive or therapeutic activities on human solid cancers; however, whether it has anticancer effects on leukemia has not yet been elucidated. The present study ... -
The microRNA-183 cluster: the family that plays together stays together.
(Oxford University Press, 2015-09-03)The microRNA (miR)183 cluster, which is comprised of miRs-183, -96 and -182, is also a miR family with sequence homology. Despite the strong similarity in the sequences of these miRs, minute differences in their seed ... -
Prenatal Diagnosis of Uhl Anomaly with Autopsy Correlation.
(Thieme Open, 2016-03)Uhl anomaly is a rare form of congenital hypoplasia of the right ventricular myocardium. Here, we report, a rare finding in fetal cardiac ultrasound in a 33-year-old woman who presented at 20 weeks' of gestation. A diagnosis ... -
Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers.
(Public Library of Science, 2015-10-01)To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the expression of microRNAs was measured in a plasma fraction enriched in exosomes by differential centrifugation, using Illumina deep ... -
Natural Allelic Variations in Glutathione Peroxidase-1 Affect Its Subcellular Localization and Function
(American Association for Cancer Research, 2014-09)Glutathione peroxidase 1 (GPx-1) has been implicated in the etiology of several common diseases due to the association between specific allelic variations and cancer risk. The most common among these variations are the ... -
Differential Effects of Genistein on Prostate Cancer Cells Depend on Mutational Status of the Androgen Receptor
(Public Library of Science, 2013)Blocking the androgen receptor (AR) activity is the main goal of therapies for advanced prostate cancer (PCa). However, relapse with a more aggressive, hormone refractory PCa arises, which harbors restored AR activity. One ... -
Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome
(BioMed Central, 2013-10)Selenium is a trace element that plays a critical role in physiological processes and cancer prevention, whose functions may be through its effects on selenium-containing proteins. Selenium-binding protein 1 (SBP1) is a ... -
AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development
(BioMed Central, 2013-04)Background: During cerebral cortical development, neural precursor-precursor interactions in the ventricular zone neurogenic niche coordinate signaling pathways that regulate proliferation and differentiation. Previous ... -
Serum phytanic and pristanic acid levels and prostate cancer risk in Finnish smokers
(Wiley Open Access, 2014)Phytanic acid is a saturated branched-chain fatty acid found predominantly in red meat and dairy products, and may contribute to the elevated risks of prostate cancer associated with higher consumption of these foods. ... -
Evidence for Heightened HKII Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma
(Springer Verlag, 2014-09-07)BACKGROUND: Normal hepatocytes exhibit low-affinity hexokinase (glucokinase [HKIV]), but during oncogenesis, there is a switch from HKIV to HKII expression. The aims of this study were to compare the immunoexpression of ... -
Real-time interactive data mining for chemical imaging information: application to automated histopathology
(BioMed Central, 2013-05)Background: Vibrational spectroscopic imaging is now used in several fields to acquire molecular information from microscopically heterogeneous systems. Recent advances have led to promising applications in tissue analysis ...
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