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glpX Gene of Mycobacterium tuberculosis: Heterologous Expression, Purification, and Enzymatic Characterization of the Encoded Fructose 1,6-bisphosphatase II
(Humana Press, 2011-03-31)
The glpX gene (Rv1099c) of Mycobacterium tuberculosis (Mtb) encodes Fructose 1,6- bisphosphatase II (FBPase II; EC 18.104.22.168); a key gluconeogenic enzyme. Mtb possesses glpX homologue as the major known FBPase. This study ...
A Two-Step Strategy for the Complementation of M. Tuberculosis Mutants
(Brazilian Genetics Society, 2011)
The sequence of Mycobacterium tuberculosis, completed in 1998, facilitated both the development of genomic tools, and the creation of a number of mycobacterial mutants. These mutants have a wide range of phenotypes, from ...
Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis
(International Union of Crystallography, 2011-06)
Fructose-1,6-bisphosphatase (FBPase; EC 22.214.171.124), which is a key enzyme in gluconeogenesis, catalyzes the hydrolysis of fructose 1,6-bisphosphate to form fructose 6-phosphate and orthophosphate. The present investigation ...