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The demise of catalysis, but new functions arise: pseudoenzymes as the phoenixes of the protein world
(Portland Press, 2019-02-01)Pseudoenzymes are noncatalytic homologues of enzymes and are found in most enzyme families. Although lacking catalytic activity and sometimes referred to as “dead” enzymes, they instead resemble phoenixes because the loss ... -
Does God roll dice? Neutrality and determinism in evolutionary ecology
(Springer, 2019-02)A tension between perspectives that emphasize deterministic versus stochastic processes has sparked controversy in ecology since pre-Darwinian times. The most recent manifestation of the contrasting perspectives arose with ... -
The use of proteomics studies in identifying moonlighting proteins
(Humana Press, 2018-10-02)Proteomics studies that characterize hundreds or thousands of proteins in parallel can play an important part in the identification of moonlighting proteins, proteins that perform two or more distinct and physiologically ... -
Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
(American Society for Biochemistry and Molecular Biology, 2018-08-31)Mixed-lineage kinase 3 (MLK3; also known as MAP3K11) is a Ser/Thr protein kinase widely expressed in normal and cancerous tissues, including brain, lung, liver, heart, and skeletal muscle tissues. Its Src homology 3 (SH3) ... -
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design
(Annual Reviews, 2018-03-23)Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein ... -
Working Title: The Spatial and Developmental Expression of Mouse Vwa8 (von Willebrand Domain-containing Protein 8)
(Elsevier, 2018-04-13)The Drosophila gene c12.2 was isolated in a screen examining mRNA binding proteins. Drosophila c12.2 is the mouse Vwa8 homolog. Various genome-wide associated studies have linked human Vwa8 to both neurological and ... -
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design
(Annual Reviews, 2018-03-23)Genetic information is translated into proteins by the ribosome. Structural studies of the ribosome and of its complexes with factors and inhibitors have provided invaluable information on the mechanism of protein ... -
Endogeic earthworm densities increase in response to higher fine root production in a forest exposed to elevated CO2
(Elsevier, 2018-07)Net primary productivity (NPP) influences soil food webs and ultimately the amount of carbon (C) inputs in ecosystems. Earthworms can physically protect organic matter from rapid mineralization through the formation of ... -
Structural and evolutionary insights into ribosomal RNA2 methylation.
(Nature Publishing Group, 2018-03)Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA ... -
Fruit-eating birds in experimental plantings in southern Mexico
(Cambridge University Press, 2017-01-01)Maintenance of biodiversity in tropical agrarian landscapes is challenging in the face of anthropomorphic simplification of habitats. As part of an experiment testing influences of planting treatment on tree recruitment ... -
Dissecting the voice: Health professions students' perceptions of instructor age and gender in an online environment and the impact on evaluations for faculty
(John Wiley and Sons Inc., 2016-11-01)Gender and age biases are well documented in academia and many studies demonstrate bias in students’ evaluation of instructors. An instructor’s violation of gender-based expectations can translate to lower scores or ... -
Evolutionary history and gene flow of an endemic Island oak: Quercus Pacifica
(Botanical Society of America Inc., 2016-12)Premise of the study: Understanding historical patterns of colonization and subsequent gene flow clarifies the evolutionary origins and history of endemic island species. Methods: Here we use DNA microsatellite markers ... -
Sex in the City: Breeding Behavior of Urban Peregrine Falcons in the Midwestern US
(Public Library of Science, 2016-07-01)Peregrine falcons (Falco peregrinus) were extirpated from most of the continental United States by widespread use of the pesticide DDT in the 1960s. Populations have rebounded with banning of the pesticide and successful ... -
Making dispersal syndromes and networks useful in tropical conservation and restoration
(Elsevier, 2016-04-01)Dispersal syndromes and networks must be used cautiously in conserving and restoring seed-dispersal processes. In many tropical forests most tree and shrub species require dispersal by animals for local persistence and for ... -
Development of microsatellite loci of pod mahogany, Afzelia quanzensis (Fabaceae), by Illumina shotgun sequencing, and cross-amplification in Afzelia africana
(Botanical Society of America, 2016-06-01)Premise of the study: Microsatellite loci were developed for Afzelia quanzensis (Fabaceae) as a first step toward investigating genetic diversity and population structure of the species in its native range. Methods ... -
Directed evolution of a highly specific FN3 monobody to the SH3 domain of human lyn tyrosine kinase
(Public Library of Science, 2016-01-05)Affinity reagents of high affinity and specificity are very useful for studying the subcellular locations and quantities of individual proteins. To generate high-quality affinity reagents for human Lyn tyrosine kinase, a ... -
Global analysis of dorsoventral patterning in the wasp Nasonia reveals extensive incorporation of novelty in a regulatory network
(BioMed Central, 2016-08-01)Background: Gene regulatory networks (GRNs) underlie developmental patterning and morphogenetic processes, and changes in the interactions within the underlying GRNs are a major driver of evolutionary processes. In order ... -
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop
(Genetics Society of America, 2015-06-01)T-box genes often exhibit dynamic expression patterns, and their expression levels can be crucial for normal function. Despite the importance of these genes, there is little known about T-box gene regulation. We have focused ... -
Phylogeny of a Genomically Diverse Group of Elymus (Poaceae) Allopolyploids Reveals Multiple Levels of Reticulation
(Public Library of Science, 2013-11-01)The grass tribe Triticeae (=Hordeeae) comprises only about 300 species, but it is well known for the economically important crop plants wheat, barley, and rye. The group is also recognized as a fascinating example of ... -
Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.
(Elsevier, 2015-11-17)Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species ...
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