Now showing items 1-4 of 4
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
(Elsevier (Cell Press), 2016-07-12)
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to ...
Bioenergetic shifts during transitions between stem cell states
(Pulmonary Circulation, 2014-09-01)
Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell ...
Metabolic Stress, Reactive Oxygen Species, and Arrhythmia
Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias are unclear. Arrhythmic conditions are ...
Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease
ObjectivesH(2)O(2) contributes to FID of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase ...