Now showing items 1-10 of 246
Efficacy and Safety of an Octreotide Implant in the Treatment of Patients With Acromegaly
(Endocrine Society, 2013-10)
Context: Acromegaly is caused by excessive GH secretion and IGF-I overproduction. The goals of treatment are to reduce GH and IGF-I values to normal and relieve the associated symptoms. Objective: The purpose of this ...
Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
(Elsevier (Cell Press), 2016-07-12)
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to ...
Bioenergetic shifts during transitions between stem cell states
(Pulmonary Circulation, 2014-09-01)
Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell ...
Skeletal Muscle Vascular Function: A Counterbalance of Insulin Action.
(Wiley Online Library, 2015-07)
Insulin is a vasoactive hormone that regulates vascular homeostasis by maintaining balance of endothelial derived nitric oxide (NO) and the potent vasoconstrictor, endothein-1 (ET-1). Although there is general agreement ...
The Rise in Growth Hormone during Starvation Does Not Serve to Maintain Glucose Levels or Lean Mass but Is Required for Appropriate Adipose Tissue Response in Female Mice
(Endocrine Society, 2013-01)
In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using ...
Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the alpha 1 or the alpha 2 isoform of the catalytic domain of AMPK
(BioMed Central, 2013-11)
Background The purpose of this study was to determine whether AMPK influences the survival of primary cultures of mouse proximal tubular (MPT) cells subjected to metabolic stress. Previous studies, using an immortalized ...
Hyperfiltration is Associated with the Development of Microalbuminuria in Patients 1 with Sickle Cell Anemia
(Wiley Periodicals Inc., 2014-12)
Recovery of Native Erythropoietin in a Patient with Erythropoietin-Associated Pure Red Cell Aplasia
(Springer Verlag, 2014-01)
Non-Silent Story on Synonymous Sites in Voltage-Gated Ion Channel Genes
(Public Library of Science, 2012-10)
Synonymous mutations are usually referred to as ‘‘silent’’, but increasing evidence shows that they are not neutral in a wide range of organisms. We looked into the relationship between synonymous codon usage bias and ...
Comparing Multiplex PCR and Rapid Urease Test in the Detection of H. pylori in Patients on Proton Pump Inhibitors
(Hindawi Publishing Corporation, 2012-11)
Background. This study was conducted to assess the diagnostic value of a multiplex PCR assay to detect H. pylori infection and to further evaluate the negative results from the CLOtest on patients with and without PPI ...