Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation
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| Title: | Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation |
| Author(s): | Eapen, Asha S.; Ramachandran, Amsaveni; Pratap, Jitesh; George, Anne |
| Subject(s): |
Dentin matrix protein 1
ERK1/2 MAP kinase |
| Abstract: | DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway. Copyright © 2011 S. Karger AG, Basel |
| Issue Date: | 2011-05-06 |
| Publisher: | Karger |
| Citation Info: | Eapen, A., Ramachandran, A., Pratap, J., & George, A. 2011. Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation. Cells Tissues Organs. DOI: 10.1159/000324258. |
| Type: | Article |
| Description: | Post print version of article may differ from published version. The definitive version is available through Karger at DOI: 10.1159/000324258 [http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000324258]. © 2011 S. Karger AG, Basel |
| URI: | http://hdl.handle.net/10027/7818 |
| ISSN: | 1422-6405 |
| Sponsor: | This work was supported by National Institutes of Health Grant DE 11657 and by the Brodie Endowment Fund. |
| Date Available in INDIGO: | 2011-06-01 |
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